NFL Picks, Predictions & Best Bets

With sharper quarterback play and a healthier depth chart, the Wise Guy Desk leans Las Vegas at home once the board opens.

With crisp quarterback play and a healthier depth chart, the Wise Guy Desk leans New England when lines post for this preseason trip to Cleveland.

With Kyle Allen dealing and the Bills unbeaten at home, the Wise Guy Desk leans Buffalo once the lines post.

With J.J. McCarthy questionable and Denver defending Mile High, the Wise Guy Desk leans Broncos once lines post, at whatever book hangs the best number.

With no line posted yet, the Wise Guy Desk explains why the 2-0 Cincinnati Bengals are the early lean at Lincoln Financial Field, and what number to wait for.

With Drew Lock playing near-perfect football and Patrick Mahomes questionable, the Wise Guy Desk leans Seattle at Arrowhead once odds post.

With Gardner Minshew II dealing and odds still unposted, the Wise Guy Desk leans Arizona Cardinals when the lines open at Lambeau Field.

The Wise Guy Desk leans Dallas at AT&T Stadium, where Joe Milton III's hot hand meets a winless New Orleans squad.

With Joey Aguilar humming and the game at EverBank, the Wise Guy Desk leans Jaguars over the unbeaten Buccaneers once a line posts.

With the Jets' backfield banged up and Jameis Winston moving the ball cleanly, the Wise Guy Desk leans Giants once the books post a number.

The Wise Guy Desk leans Carolina at home, where a 2-1 Panthers squad hosts a Houston team still searching for its first win.

With Jack Strand humming and Miami's offense stuck in neutral, the Wise Guy Desk leans Falcons once the line posts.

With Baltimore at 2-0, playing at home, and getting the cleaner injury report, the Wise Guy Desk leans Ravens once the line posts.

The Wise Guy Desk leans Titans at home, where Cam Ward's efficiency and Tennessee's 2-0 momentum outclass a Bears team dealing with quarterback-room injuries.

The Wise Guy Desk leans Detroit at Lucas Oil Stadium, but only at the right number once books post it.

The market makes Seattle a clear favorite at Lumen Field, but the Wise Guy Desk sees the smarter number sitting with New England plus the points.

The Wise Guy Desk sees the value on the San Francisco 49ers plus 3.5 points at -105 with FanDuel in this NFC West opener at the Melbourne Cricket Ground.

The market makes Dallas a short road favorite, but the sharper number sits with the Giants plus 2.5 at -102 (Caesars).

The Chargers are massive favorites at SoFi, but with their offensive line dealing with injuries, the Wise Guy Desk sees the value on Arizona catching 10.5 points at DraftKings.

The market gives Washington a 35% chance, but FanDuel's +198 pays like they have less, and that gap is where the Wise Guy Desk is leaning Commanders moneyline.

The market makes Minnesota a slim home favorite, and the Wise Guy Desk sees the Vikings moneyline at -110 as the tightest price on the board.

The Wise Guy Desk sees value in taking Miami plus the points at the best available number in Las Vegas.

With the market at a dead-even 50-50, we like Houston at -102 on the moneyline at DraftKings, the cheapest ticket on the board.

The market makes Jacksonville a heavy favorite, but the math says the smarter play is Cleveland plus 7.5 points at -105 on FanDuel.

The market makes Chicago a short road favorite, but the smarter number sits on Carolina plus 2.5 at plus money.

The market makes Pittsburgh the favorite, but the Wise Guy Desk sees the value on Atlanta plus the points at even money.

The market makes Baltimore a clear favorite, but the extra half point on Indianapolis is where the math tilts, and Colts +3.5 at BetRivers is our lean.

With the Jets backfield banged up and the market leaning Tennessee at home, our value read lands on Titans -2.5 at -105 (FanDuel).

The market makes Detroit a heavy favorite at Ford Field, but the math says the sneaky number is New Orleans at +290 on the moneyline at FanDuel.