NFL Picks, Predictions & Best Bets

With both teams sitting at 0-1, the Wise Guy Desk leans Houston at home once the books hang a number.

With Denver healthier and at altitude, the Wise Guy Desk leans Broncos at home once the board opens.

With Carolina banged up along the interior and Jacksonville sitting at 1-0 at home, the Wise Guy Desk leans Jaguars once the board opens.

With three Pittsburgh corners sidelined, the Wise Guy Desk leans New York Jets once the line posts, and shopping every book for the best number.

With Josh Sweat out and James Conner questionable in the desert, the Wise Guy Desk leans Dallas once the board opens.

With Patrick Mahomes questionable and Tampa Bay sitting at 1-0 at home, the Wise Guy Desk leans Buccaneers once a line posts.

With Jonathan Greenard out for Philadelphia and the Patriots at home, the Wise Guy Desk leans New England at Gillette Stadium once a number posts.

With Chicago's secondary shorthanded and Cincinnati closer to whole at home, the Wise Guy Desk leans Bengals at Paycor Stadium once the lines post.

With Malik Nabers questionable and the Dolphins at home, the Wise Guy Desk leans Miami once the number posts.

With the Saints missing key defensive linemen and the Rams healthier and at home, our lean is Los Angeles once lines post.

With Baltimore missing three defensive starters and Minnesota near full strength at home, the Wise Guy Desk leans Vikings once the odds post.

With Michael Penix Jr. questionable and the Falcons still searching for their first win, the Wise Guy Desk leans Colts at Lucas Oil Stadium once a number posts.

With Cleveland shorthanded and Buffalo rolling in at 1-0, the Wise Guy Desk leans Bills once the board opens.

With Detroit missing Brian Branch and Washington arriving 1-0, the Wise Guy Desk leans Commanders once a line posts at Ford Field.

With Seattle down a key defender and Tennessee at full strength off a win, the Wise Guy Desk leans Titans at Nissan Stadium once a number posts.

The market makes Seattle a clear favorite at Lumen Field, but the smarter number sits on New England's moneyline at +185.

The Wise Guy Desk sees the value on the San Francisco 49ers plus 3 points at even money at DraftKings in a tight NFC West rematch.

With three Chargers starters questionable and a fat 10.5-point number, the value sits with the Cardinals plus the points at Caesars.

The market makes Philadelphia a heavy favorite, but the smart money angle sits with Washington at +4.5 (-108) at Caesars.

The market calls this a coin flip, and that is exactly why the Minnesota Vikings plus a point at -103 (Caesars) is where the value lives.

The market makes Las Vegas a clear favorite at home, but the math says the smarter ticket is Miami's moneyline at +176 on FanDuel.

In a game the market calls a near coin flip, the Wise Guy Desk leans Texans +1.5 at -120 (DraftKings) and keeps the points in its pocket.

The Jaguars are heavy home favorites, but the Wise Guy Desk sees the value on the Browns catching 7.5 points at FanDuel.

Two division leaders meet in Charlotte, and the Wise Guy Desk sees the value with Carolina Panthers +2.5 at -105 on FanDuel.

The Wise Guy Desk likes the Atlanta Falcons plus 3 points at even money (+100) at DraftKings against a Steelers team laying a short number at home.

The market makes Baltimore a clear favorite in Indianapolis, but the Wise Guy Desk sees the value sitting with the Colts plus the points at FanDuel.

Two teams sitting last in their divisions meet in Nashville, and the smart money says take the New York Jets plus the points at even money.

The Wise Guy Desk sees the value on the Saints plus 7 points at -106 with FanDuel, the best number on the board.

The Wise Guy Desk sees the smartest number in this one on Tampa Bay +3.5 at -108 with Caesars.