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Minnesota Vikings play at San Francisco 49ers in the NFL on Sunday, November 22, at Estadio Banorte. As of 2:54 AM ET, 49ers are 3.5-point favorites and the total is 45.5. Prices come from 9 sportsbooks we track. The Desk leans Vikings ML. A prediction is an estimate from the market and the matchup, not a certain result.
Prices updated · from 9 sportsbooks · NFL betting splits
Neither Kalshi nor Polymarket has a market on this game that we can match, so there is no exchange buyer data to show.
Polymarket US lists moneyline, spread, total, team totals and alternate and period lines for this game. No trade split yet for these markets (none captured, or too few to show), so they show prices only. Polymarket US is a separate venue from Polymarket (international) and is never added into its numbers.
| Market | Minnesota Vikings | San Francisco 49ers |
|---|---|---|
| Moneyline | +188Bet at FanDuel → | -205Bet at DraftKings → |
| Spread | +3.5 -105Bet at DraftKings → | -3.5 -114Bet at Caesars → |
| Total 45.5 | O -109Bet at BetRivers → | U -105Bet at DraftKings → |
As of 2:54 AM ET, the spread is 49ers -3.5 and the total is 45.5, with 9 sportsbooks priced and the table showing each book's own number.
| Sportsbook | Vikings ML | 49ers ML | Vikings spread | 49ers spread | Over | Under |
|---|---|---|---|---|---|---|
| Bally Bet | +170 | -210 | +3.5 -107 | -3.5 -114 | O 45.5 -109 | U 45.5 -112 |
| betPARX | +170 | -210 | +3.5 -107 | -3.5 -114 | O 45.5 -109 | U 45.5 -112 |
| BetRivers | +170 | -210 | +3.5 -107 | -3.5 -114 | O 45.5 -109 | U 45.5 -112 |
| Caesars | +173 | -209 | +3.5 -106 | -3.5 -114 | O 45.5 -110 | U 45.5 -110 |
| DraftKings | +170 | -205 | +3.5 -105 | -3.5 -115 | O 45.5 -115 | U 45.5 -105 |
| bet365 | +180 | -220 | – | – | O 45.5 -112 | U 45.5 -108 |
| FanDuel | +188 | -225 | – | – | O 45.5 -110 | U 45.5 -110 |
| ReBet | +175 | -220 | – | – | O 45.5 -110 | U 45.5 -110 |
| Novig | +186 | -233 | – | – | – | – |
Prices from 9 sportsbooks we track, updated . Prices move, so check the book before you bet.
Our no-vig fair price on this game is for members. The posted odds are on this page; the fair line, and whether any book is hanging a number worth betting, live in the members' Odds Screen. Start your $1 trial →
Minnesota Vikings3rd in the NFC NorthSan Francisco 49ers1st in the NFC West
Brock Purdy (SF)163/236, 1,980 YDS, 17 TD, 5 INT (8 GP)
Aaron Jones Sr. (MIN)115 CAR, 474 YDS, 2 TD (8 GP)That rarely happens, and it means this game is less about who is better and more about who is priced right. The Minnesota Vikings visit the San Francisco 49ers at Estadio Banorte in Week 11 on Sunday, November 22, at 8:20 PM ET on NBC. The quarterback news on one side could shape everything.
As of November 11, the Vikings are 6-2 and sit 3rd of 4 in the NFC North. The 49ers are 7-1 and sit 1st of 4 in the NFC West. Both teams are winning. The difference is that the Vikings are chasing inside their division while the 49ers are setting the pace in theirs. Those records are a snapshot from publication, not a promise of where either team stands at kickoff.
Brock Purdy drives the 49ers. Over eight games he has completed 163 of 236 passes for 1,980 yards, 17 touchdowns and 5 interceptions. That works out to 247.5 yards and 2.1 touchdowns per game, which is steady, efficient production. For the Vikings, Aaron Jones Sr. leads the ground game with 474 yards and 2 touchdowns on 115 carries over eight games, about 59.3 yards per game. If Jones keeps the Vikings ahead of schedule, they can shorten the game and keep Purdy on the sideline.
The moneyline is a bet on who wins, nothing else. The 49ers are the favorite at -205 (best at DraftKings). The minus sign means you risk more than you profit, so a $100 bet profits $48.78. The Vikings are the underdog at +190 (best at FanDuel), so $100 profits $190. The Vikings vs 49ers spread is a separate bet on the margin. The Vikings at +3.5 (-105, DraftKings) win if they win outright or lose by 3 or fewer, and a 4-point loss sinks it.
The 49ers at -3.5 (-114, Caesars) must win by 4 or more. The total of 45.5 is a bet on combined points: Over at -109 (BetRivers) or Under at -105 (bet365). Prices like -105 include the sportsbook's fee, called the vig. Strip it out and the Vikings vs 49ers odds read about 65.7% for the 49ers to win and 34.3% for the Vikings. Every price above is the best we found across the books we track.
Every price has a break-even, the win rate where you neither make nor lose money over time. Expected value is the average result per bet if you could play it many times. Vikings +190 breaks even at 34.5%. Nothing on this board is positive. The Vikings moneyline gives up the least.
Kyler Murray is listed Doubtful, and we are treating him as absent. Carson Wentz is listed Active. Jauan Jennings, Tyrion Ingram-Dawkins and Theo Jackson are Questionable, and Demond Claiborne is on Injured Reserve. For the 49ers, Brandon Aiyuk is Out. Christian Kirk, Gracen Halton and C.J. West are on Injured Reserve. Mike Evans, Deebo Samuel Sr. and Deommodore Lenoir are Questionable. Christian McCaffrey and George Kittle are Active. Questionable means uncertain, so check the final designations before kickoff on Sunday.
Our pick is the Vikings moneyline at +190 at FanDuel. To be clear, this is a near break-even play, not a positive one. Use a small stake and only the best number. Anything shorter than +190 is a pass.
We expect a grinding game. Jones keeps the Vikings on schedule. The 49ers have a thin receiving room, with Aiyuk out and Evans and Samuel questionable, so Purdy has fewer clean options. Our projection is Vikings 23, 49ers 20. That adds up to 43 points, under the 45.5 total. That is our read on this number. The Desk posts a documented free play on days like this, and it sits right below.
49ers is the market favorite at -205 (best price at DraftKings) on the moneyline, with Vikings at +188. Lines move all day, so check the odds table on this page for the current best number at every book.
The Minnesota Vikings at San Francisco 49ers game airs on NBC. It is played at Estadio Banorte on Sunday, November 22, 2026, with kickoff set for 8:20 PM Eastern time, according to the ESPN scoreboard listing.
Kickoff is Sunday, November 22, 2026, at 8:20 PM Eastern time. This is a Week 11 regular season game at Estadio Banorte, and it is broadcast on NBC.
The San Francisco 49ers are the favorite at -205 on the moneyline (best at DraftKings), and the Minnesota Vikings are the underdog at +190 (best at FanDuel). With the vig removed, the market reads about 65.7% for the 49ers and 34.3% for the Vikings.
Minnesota Vikings vs San Francisco 49ers NFL prediction, picks and best bet from the Wise Guy Desk. The full read, including a projected final score, is in The Prediction section above.
The total is 45.5, with the over priced at -109 at BetRivers and the under at -105 at DraftKings. A total is a bet on the combined score of both teams, over or under that number, no matter who wins.
Yes. This is a free Wise Guy Desk breakdown, our analysis, not Ross's official plays. Ross's documented plays are bet with real money and graded win or loss on the members board.
Expected value first: the best price across the regulated US books we track versus the true fair price with the vig removed, then the matchup data (form, standings, injuries, key players). Line shopping for the best number is the edge most bettors leave on the table.
Forecast for Estadio Banorte near game time: 66ยฐF, wind 3 mph from the ENE. Weather data: MET Norway (CC BY 4.0), captured 2026-11-15 05:09 UTC.
More for this game: NFL public betting splits · DraftKings betting splits · NFL odds · FanDuel betting splits
Depth chart starters: Minnesota Vikings Kyler Murray, San Francisco 49ers Brock Purdy.
Minnesota Vikings: Aaron Jones Sr. (active), Andrew Van Ginkel (active), Caleb Banks (active), Carson Wentz (active); San Francisco 49ers: Brandin Cooks (active), Brandon Aiyuk (out), Brock Purdy (active), C.J. West (injured reserve).
As of Nov 11, 7:16 AM ET, when this preview was written. Percentages are public betting splits and market prices, not picks.
This preview was produced with AI assistance from live data feeds and reviewed by automated checks. Odds and availability change constantly and may differ from what's shown - always verify the current line at your sportsbook before betting. Found an error? memberservice@wiseguyteam.com.
21+. For entertainment and educational purposes, not financial advice. Wise Guy Desk reads are analysis, not guaranteed outcomes. If gambling stops being fun, take a break. 1-800-GAMBLER.