San Francisco 49ers injury report, ATS record and schedule
In 7 stored NFL regular-season games in 2026, the San Francisco 49ers are 6-1 straight up, 4-3 against the spread in 7 games with a closing line, 3-4 on the over-under. The injury list below shows 10 players with a status, as of Oct 27, 2026, 1:13 AM ET.
What is the San Francisco 49ers injury report?
As of Oct 27, 2026, 1:13 AM ETThe San Francisco 49ers list 10 players on the injury report as of Oct 27, 2026, 1:13 AM ET: 8 out or on injured reserve, 0 doubtful and 2 questionable or day to day.
Out or injured reserve (8)
Questionable or day to day (2)
What is the San Francisco 49ers record against the spread?
The San Francisco 49ers are 4-3 against the spread (57% covers, pushes not counted) in 7 NFL games with a closing line in 2026.
How do the San Francisco 49ers do on short rest and after long travel?
| Situation | Games | Straight up | Against the spread (games with a line) |
|---|---|---|---|
| Short week (6 days or fewer) | 6 | 5-1 | 4-2 (6) |
| Long trip (1,500 km or more, or 2+ time zones) | 3 | 2-1 | 2-1 (3) |
| Everything else | 6 | 5-1 | 5-1 (6) |
The team's own side of each stored game this season; rest and travel are computed from the stored schedule. Buckets under 3 games are left out. Past results are context, not a prediction.
How has the San Francisco 49ers injury list changed game by game?
The San Francisco 49ers listed an average of 2.8 players out per game over their last 6 games with a stored list.
| Game | Out | Doubtful | Questionable | Listed |
|---|---|---|---|---|
| Oct 19 | 4 | 0 | 6 | 19 |
| Oct 11 | 4 | 0 | 2 | 13 |
| Oct 4 | 3 | 0 | 4 | 11 |
| Sep 27 | 4 | 0 | 1 | 8 |
| Sep 20 | 1 | 0 | 2 | 12 |
| Sep 10 | 1 | 0 | 1 | 11 |
For each game, the last injury list stored before it started. Statuses are the league's own wording grouped as out, doubtful and questionable.
How have the San Francisco 49ers done against the spread since 2020?
101 gamesOver the 2020 to 2025 seasons (101 regular-season games), the San Francisco 49ers went 52-49 against the spread in the 101 games with a stored closing line (51% covers, pushes not counted), 59-42 straight up, and 54-44-3 on the over-under.
| Season | Record | ATS | Over-under | Lines stored |
|---|---|---|---|---|
| 2025 | 12-5 | 11-6 | 10-7 | 17 of 17 |
| 2024 | 6-11 | 5-12 | 10-6-1 | 17 of 17 |
| 2023 | 12-5 | 9-8 | 9-7-1 | 17 of 17 |
| 2022 | 13-4 | 11-6 | 9-8 | 17 of 17 |
| 2021 | 10-7 | 9-8 | 8-8-1 | 17 of 17 |
| 2020 | 6-10 | 7-9 | 8-8 | 16 of 16 |
| Total | 59-42 | 52-49 | 54-44-3 | 101 of 101 |
San Francisco 49ers results and closing lines
7 games| Date | Opponent | Score | Result | Closing line | ATS | Total |
|---|---|---|---|---|---|---|
| Oct 25 | at Atlanta Falcons | 20-29 | L | -2.5 | No cover | Under 49.5 |
| Oct 19 | vs Washington Commanders | 23-17 | W | -7 | No cover | Under 51.5 |
| Oct 11 | at Seattle Seahawks | 32-29 | W | +3 | Cover | Over 46.5 |
| Oct 4 | vs Denver Broncos | 24-14 | W | -3 | Cover | Under 48.5 |
| Sep 27 | vs Arizona Cardinals | 36-30 | W | -7.5 | No cover | Over 48.5 |
| Sep 20 | vs Miami Dolphins | 35-13 | W | -12.5 | Cover | Over 44.5 |
| Sep 10 | at Los Angeles Rams | 27-7 | W | +3.5 | Cover | Under 47.5 |
Results, closing lines and injury lists are stored facts, shown with their sample and time. Past results are context, not a prediction.