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Arizona Cardinals vs San Francisco 49ers history: series record and results

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In 13 stored NFL meetings, the San Francisco 49ers lead 8-5. The average combined score is 50.2. The most recent game was on Sep 27, 2026: Cardinals 30, 49ers 36. Against the closing spread, Arizona Cardinals covered 4 and San Francisco 49ers covered 6 (10 games with a line).

Who has won more Arizona Cardinals vs San Francisco 49ers games?

13 stored meetings

In 13 stored meetings, the San Francisco 49ers lead 8-5.

Arizona Cardinals wins5of 13 games
San Francisco 49ers wins8of 13 games
Average combined score50.213 games
Arizona Cardinals covered410 games with a line
San Francisco 49ers covered610 games with a line
Meetings counted: the 2020 season through now; older meetings are not included. Covers are graded on the closing line (our line history, else the published closing line).

Arizona Cardinals vs San Francisco 49ers results

Newest first
DateHome teamFinalWinnerCardinals lineAgainst the spread
Sep 27, 2026San Francisco 49ersCardinals 30, 49ers 36San Francisco 49ers+7.5Arizona Cardinals covered
Nov 16, 2025Arizona CardinalsCardinals 22, 49ers 41San Francisco 49ers+3.5San Francisco 49ers covered
Sep 21, 2025San Francisco 49ersCardinals 15, 49ers 16San Francisco 49ersn/an/a
Jan 5, 2025Arizona CardinalsCardinals 47, 49ers 24Arizona Cardinalsn/an/a
Oct 6, 2024San Francisco 49ersCardinals 24, 49ers 23Arizona Cardinalsn/an/a
Dec 17, 2023Arizona CardinalsCardinals 29, 49ers 45San Francisco 49ers+12.5San Francisco 49ers covered
Oct 1, 2023San Francisco 49ersCardinals 16, 49ers 35San Francisco 49ers+15San Francisco 49ers covered
Jan 8, 2023San Francisco 49ersCardinals 13, 49ers 38San Francisco 49ers+14San Francisco 49ers covered
Nov 21, 2022Arizona CardinalsCardinals 10, 49ers 38San Francisco 49ers+10San Francisco 49ers covered
Nov 7, 2021San Francisco 49ersCardinals 31, 49ers 17Arizona Cardinals+5.5Arizona Cardinals covered
Oct 10, 2021Arizona CardinalsCardinals 17, 49ers 10Arizona Cardinals-6Arizona Cardinals covered
Dec 26, 2020Arizona CardinalsCardinals 12, 49ers 20San Francisco 49ers-6San Francisco 49ers covered
Sep 13, 2020San Francisco 49ersCardinals 24, 49ers 20Arizona Cardinals+7Arizona Cardinals covered
Line shown from the Arizona Cardinals side (negative = favorite).Swipe the table sideways for every column.

Results and closing lines are stored facts, shown with their sample. Past results are context, not a prediction.

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