MLS Picks, Predictions & Best Bets

The market leans Real Salt Lake, but the math says the only price worth paying is FC Dallas at +275.

With lines still unposted, the Wise Guy Desk leans LAFC on the three-way moneyline once books hang a number worth taking.

Two out-of-form sides and a fair price on the stalemate make the draw at +330 the sharpest angle at Allianz Field.

St. Louis rolls into Kansas City on a five-match unbeaten run, and the Wise Guy Desk leans CITY SC at -110 with BetRivers.

Houston rides a four-game win streak into BC Place, and the +600 price at FanDuel is where the Wise Guy Desk sees the value.

The market makes Portland a home favorite at plus money, and +108 at BetRivers is the sharpest number on the board.

Two cold California rivals meet in Carson, and the Wise Guy Desk sees the most defensible number on the draw at +290 at FanDuel.

Charlotte's winning form and a near-fair +193 at Caesars make the road side the sharpest way to attack this Toronto board.

Nashville's steadier five-game run makes the visitors our early lean at Red Bull Arena, pending an opening price worth taking.

With both win prices carrying extra juice, the draw at +325 (Fanatics) is the sharpest number on the board in Chester.

With Chicago riding five straight wins and still priced at plus money, the Wise Guy Desk leans Fire at +133 in Orlando.

Cincinnati's home form against a slumping NYCFC makes the Wise Guy Desk lean host side at -110 with Fanatics.

The market calls this a near coin flip, and New England at +170 at BetRivers is the closest thing to a fair price on the board.

With Columbus riding a 3-1-1 stretch and Montréal winless in five, the Wise Guy Desk leans Crew at home once the lines post.

With Vancouver winless in five yet priced as a road favorite, the value math points to Seattle at +310 with BetRivers.

Austin FC at +205 is the only price on this board with positive expected value, and that makes the home side the Wise Guy Desk lean.

Philadelphia's steadier recent form makes the Union at +165 (FanDuel) the Wise Guy Desk lean at Yankee Stadium.

The market makes Chicago a heavy favorite, but the math points to Portland at +430 as the live-underdog value play.

The form gap screams St. Louis, and +200 at FanDuel is the number the Wise Guy Desk wants.

Two of the West's hottest teams collide at BMO Stadium, and the Wise Guy Desk leans LAFC on home soil once the lines post.

The market is heavy on Real Salt Lake at home, but the math points to Minnesota United at +375 with Fanatics.

The sharpest number on the board is the draw at +400 with Fanatics, the only price on this match that carries zero house edge.

The market can barely split these two, and the sharpest number on the board is Nashville SC at +147 with Caesars.

Houston is hot and priced like it, so the Wise Guy Desk leans to the draw at +310 with Fanatics in a matchup dripping with stalemate signals.

Two draw-heavy sides collide at BMO Field, and the Wise Guy Desk sees the stalemate at +280 as the sharpest number on the board.

Cincinnati at +185 is the only number in this market priced at fair value, and that is where the Desk leans.

Columbus arrives unbeaten in five, and the +200 price at Fanatics is where the Wise Guy Desk sees the smartest play.

With Montréal winless in five and D.C. United unbeaten in five, the Wise Guy Desk leans D.C. United on the double chance once prices post.

With Atlanta winless in five and Red Bulls showing signs of life, the Wise Guy Desk leans to New York on the road once odds post.