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Arizona Cardinals play at Kansas City Chiefs in the NFL on Sunday, November 22, at Arrowhead Stadium. As of 1:38 AM ET, Chiefs are 14.5-point favorites and the total is 41.5. Prices come from 9 sportsbooks we track. The Desk leans Cardinals +14.5. A prediction is an estimate from the market and the matchup, not a certain result.
Prices updated · from 9 sportsbooks · NFL betting splits
Neither Kalshi nor Polymarket has a market on this game that we can match, so there is no exchange buyer data to show.
Polymarket US lists moneyline for this game. No trade split yet for these markets (none captured, or too few to show), so they show prices only. Polymarket US is a separate venue from Polymarket (international) and is never added into its numbers.
| Market | Arizona Cardinals | Kansas City Chiefs |
|---|---|---|
| Moneyline | +750Bet at FanDuel → | -- |
| Spread | +14.5 -110Bet at Caesars → | -14.5 -105Bet at FanDuel → |
| Total 41.5 | O -114Bet at bet365 → | U -105Bet at FanDuel → |
As of 1:38 AM ET, the spread is Chiefs -14.5 and the total is 41.5, with 9 sportsbooks priced and the table showing each book's own number.
| Sportsbook | Cardinals ML | Chiefs ML | Cardinals spread | Chiefs spread | Over | Under |
|---|---|---|---|---|---|---|
| bet365 | +700 | -1100 | +14.5 -115 | -14.5 -105 | O 41.5 -114 | U 41.5 -106 |
| Caesars | +650 | -1000 | +14.5 -110 | -14.5 -109 | O 41.5 -115 | U 41.5 -106 |
| FanDuel | +750 | -1200 | +14.5 -115 | -14.5 -105 | O 41.5 -115 | U 41.5 -105 |
| Novig | +545 | -900 | +14.5 -127 | -14.5 -113 | – | – |
| ReBet | +750 | -1408 | – | – | O 41.5 -120 | U 41.5 -109 |
| Bally Bet | +650 | -1115 | – | – | – | – |
| betPARX | +650 | -1115 | – | – | – | – |
| BetRivers | +650 | -1115 | – | – | – | – |
| DraftKings | +625 | -950 | – | – | – | – |
Prices from 9 sportsbooks we track, updated . Prices move, so check the book before you bet.
Arizona Cardinals4th in the NFC WestKansas City Chiefs2nd in the AFC West
Patrick Mahomes (KC)177/263, 2,037 YDS, 14 TD, 4 INT (8 GP)
Tyler Allgeier (ARI)89 CAR, 369 YDS, 2 TD (9 GP)Kansas City is laying 14.5 points at home, and Arizona pays +750 if it simply wins. That is the market calling this a mismatch. Our job is to ask whether the price already knows that. The Arizona Cardinals visit the Kansas City Chiefs at Arrowhead Stadium on Sunday, November 22, with kickoff at 1:00 PM ET on CBS. Anyone hunting for a Chiefs vs Cardinals prediction is really asking one question: can Kansas City win by 15 or more?
Kansas City, clearly. As of November 14, the Chiefs are 6-2 and second of four in the AFC West. The Cardinals are 3-6 and fourth of four in the NFC West. This is a cross-conference game, so no division race rides on it. The quarterback picture tilts the same way. Gardner Minshew II is on injured reserve, and Arizona's depth chart lists Jacoby Brissett at quarterback. Kansas City has Patrick Mahomes.
Mahomes has played all 8 Chiefs games, going 177 of 263 for 2,037 yards, 14 touchdowns and 4 interceptions. Per game over those 8 games, that is 254.6 passing yards, 1.8 touchdowns and 0.5 interceptions. Steady, efficient, and the engine of anything Kansas City does. Arizona's listed leader is running back Tyler Allgeier, who has 89 carries for 369 yards and 2 touchdowns over 9 games, about 9.9 carries and 41 yards per game. If the Cardinals want to keep this close, they need Allgeier moving the chains and draining the clock.
The moneyline is a bet on who wins outright. Arizona Cardinals +750 at FanDuel means $100 risked profits $750 if Arizona wins. A Chiefs moneyline is not on our board. The point spread is a handicap. Cardinals +14.5 at -110 (best at Caesars) wins if Arizona wins or loses by 14 or fewer, and loses on a 15-point loss.
The half point means no push (a tie that refunds your bet). The -110 is the price: a $100 bet profits $90.91. That gap is the vig, the book's fee. The total, or over/under, is a bet on combined points: 42. The Over at -110 and the Under at -109 are both best at Caesars. Shopping books matters. The same bet pays different amounts in different places.
Break-even is how often a bet must win just to avoid losing money over time. The no-vig number is the market's implied chance with the fee stripped out. Expected value is your average result per $100 risked over many repeats. Chiefs -14.5 needs 51.2% against 48.8%, minus $4.65. The Over is minus $4.55 and the Under minus $4.13. Every price here is negative expectation. The least negative is Cardinals +14.5.
Kenneth Walker III, Jaylon Moore and Peter Woods are listed as out for Kansas City and will not play. Running back Jaydn Ott and Mansoor Delane are questionable, meaning uncertain. Arizona has Minshew and Zachary Carter on injured reserve, and Jon Gaines II and Hjalte Froholdt will not play. Jayden Williams, safety Andrew Wingard and defensive end Darius Robinson are questionable. Watch for final designations before Sunday's kickoff.
We lean Arizona Cardinals +14.5 at -110 at Caesars. Be clear on what this is. It is a matchup lean, not a value play, because its 52.4% break-even sits above the market's 51.2% cover read. Our reasoning: a 42 total points to a slower game with fewer scoring chances, and that makes a 15-point margin harder to build. Size it small.
Kansas City controls this one, and Mahomes is the difference. But Arizona leans on the run, shortens the afternoon, and stays just inside the number. We project Chiefs 27, Cardinals 14. That adds up to 41 points, one under the 42 total, and a 13-point margin that keeps the Cardinals +14.5 ticket alive by a single point. That is our read on this Cardinals vs Chiefs number; the Desk posts a documented free daily play, and it sits right below.
A 6-2 Kansas City team is laying more than two touchdowns to a 3-6 Arizona team playing without Gardner Minshew II, and the market says the margin is close to a coin flip.
The Arizona Cardinals at Kansas City Chiefs game airs on CBS. It is played at Arrowhead Stadium in Kansas City on Sunday, November 22, 2026, with kickoff set for 1:00 PM Eastern time.
The Kansas City Chiefs are favored. The best spread we track has Kansas City at -14.5 (-105 at FanDuel), and the Arizona Cardinals are +750 on the moneyline at FanDuel. The market's no-vig read gives Arizona roughly a 10% chance to win outright.
Kickoff is Sunday, November 22, 2026 at 1:00 PM Eastern time at Arrowhead Stadium. The game is a Week 11 regular season matchup and will be broadcast on CBS.
A 6-2 Kansas City team is laying more than two touchdowns to a 3-6 Arizona team playing without Gardner Minshew II, and the market says the margin is close to a coin flip. The full read, including a projected final score, is in The Prediction section above.
The total is 41.5, with the over priced at -114 at bet365 and the under at -105 at FanDuel. A total is a bet on the combined score of both teams, over or under that number, no matter who wins.
Yes. This is a free Wise Guy Desk breakdown, our analysis, not Ross's official plays. Ross's documented plays are bet with real money and graded win or loss on the members board.
Expected value first: the best price across the regulated US books we track versus the true fair price with the vig removed, then the matchup data (form, standings, injuries, key players). Line shopping for the best number is the edge most bettors leave on the table.
More for this game: NFL public betting splits · DraftKings betting splits · NFL odds · FanDuel betting splits
Depth chart starters: Arizona Cardinals Jacoby Brissett, Kansas City Chiefs Patrick Mahomes.
Arizona Cardinals: Albert Reese IV (active), Andrew Wingard (questionable), Bam Knight (active), Budda Baker (active); Kansas City Chiefs: Ben VanSumeren (active), Chris Jones (active), Cyrus Allen (active), Diego Pounds (active).
As of Nov 14, 1:56 PM ET, when this preview was written. Percentages are public betting splits and market prices, not picks.
This preview was produced with AI assistance from live data feeds and reviewed by automated checks. Odds and availability change constantly and may differ from what's shown - always verify the current line at your sportsbook before betting. Found an error? memberservice@wiseguyteam.com.
21+. For entertainment and educational purposes, not financial advice. Wise Guy Desk reads are analysis, not guaranteed outcomes. If gambling stops being fun, take a break. 1-800-GAMBLER.